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KMID : 0371320000590060746
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Journal of the Korean Surgical Society
2000 Volume.59 No. 6 p.746 ~ p.750
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The Expression of bFGF m-RNA in Gastric Cancer Tissues
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Kim Young-Woo
Han Ho-Seong
Kim Jin-Pok
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Abstract
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Purpose: The production of basic fibroblast growth factor (bFGF) which is known to have a strong angiogenic activity in gastric cancer, was evaluated.
Methods: Using alkaline phosphoatase - labelled, synthetic oligonucleotide probe of bFGF genes, the expression of the gene was evaluated in 9 fresh advanced gastric cancer tissues by using in-situ hybridization.
Results: In-situ hybridization of bFGF mRNA showed a positive reaction in 8 of 9 patients.
Conclusion: Basic fibroblast growth factor is expressed in 88% of gastric cancer tissues. In view of the profuse expression of angiogenic growth factor, future therapeutic targeting for angiogenesis could be reasonable in patients with gastric cancer.
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KEYWORD
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Gastric cancer, Basic fibroblast growth factor, In-situ hybridization, mRNA,
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